Louise is a census-designated place in Wharton County, Texas, United States. The population was 995 as of the 2010 census.Louise is located at 29°6′42″N 96°24′37″W / 29.11167°N 96.41028°W / 29.11167; -96.41028.According to the United States Census Bureau, the CDP has a total area of 6.6 square miles, all land.Louise is served by the Louise Independent School District.